Nano particles to kill Cancer
Using lasers and nanoparticles, scientists at Rice University have discovered a new technique to single person and destruction of diseased cells with small explosions. The scientists used a laser to create “nanoburbujas” zapping gold nanoparticles inside cells. In tests on cancer cells, they found they could adjust the laser to create or small, glowing bubbles that were visible but harmless or large bubbles that burst cells.
“A cell targeting is one of the most touted benefits of nanomedicine, and our approach fulfills that promise with a localized effect within an individual cell,” said physicist Dmitri Lapotko Rice, principal investigator of the project. “The idea is to detect and treat diseased cells before an illness progresses to the point of making people very sick.”
The research is available online in the journal Nanotechnology.
Nanoburbujas are created when gold nanoparticles are hit by laser pulses. The short-lived bubbles are very bright and can be smaller or larger by varying the laser power. Because they are visible under a microscope, nanoburbujas can be used for diagnosis of diseased cells or to keep track of explosions destroyed.
In laboratory studies, published last year, Lapotko and colleagues at the Laboratory for Laser Cytotechnologies the AV Lykov Heat and Mass Transfer Institute in Minsk, Belarus, nanoburbujas applied to arterial plaque. They found they could blast right through the deposits that block arteries.
“The bubbles work like a jackhammer,” said Lapotko.
In the current study, and Rice Lapotko colleague Jason Hafner, associate professor of physics and astronomy and chemistry, the test approach for leukemic cells and cells of head and neck. Antibodies are attached to the nanoparticles so that would target only cancer cells and found the technique was effective in locating and killing cancer cells.
Lapotko said the technology could be used to nanobubble “theranostics,” a unique process that combines diagnosis and therapy. Furthermore, due to rupture of nanoburbujas cells also appear in the microscope in real time, Lapotko said the technique can be used to assess post-treatment, or what doctors often refer to as “guidance.”
Hafner, said, “The mechanical and optical properties of bubbles offer unique advantages in locating biomedical applications at the level of individual cells, or even to work inside cells.
The research result of collaboration between Rice and Lykov Institute of the Academy of Sciences of Belarus, who recently established the US-Belarus Biomedical Research Laboratory of Nanophotonics fundamental.
Co-authors of the role of nanotechnology are Ehab Hanna, University of Texas MD Anderson Cancer Center and Lukyanov-Hleb Ekaterina Lykov Institute.